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FOUNDATION LEADERSHIP
President
Mahesh K. Shetty MD;FRCR;FACR;FAIUM
Clinical Professor
Baylor College of Medicine
Medical Director
Woman's Clinic for Breast
and Gynecological Imaging & Pink Door Imaging Center
Patron
Dr Kiran Mazumdar-Shaw
Chairman & Managing Director
Biocon Limited
Bangalore, India
Board of Trustees
Ron Somers
President
US-India Business Council
Washington D.C.
Jennifer Garza
CEO Edinburg Regional Medical Center/Edinburg Children's Hospital
Edinburg, Texas
Mrs. Mona Parikh PHR, MBA
Sr. Human Resources Business
Partner
Mr Andrew Novarini
CEO, Cypress Station Branch
Bank of Houston
Kelli Cohen MD
General and Pediatric Radiologist
Eric S. Greisel J.D.
General Legal Counsel
PROGRAM ADVISOR
Loretta A. Hanser
Director of Imaging Services
Mammography, CHP Radiology
Harris County Hospital District
Regional Directors
Mrs. Trishna Dey [Asia]
Ms. Esther Biira [Africa]
Dr Adhmer Longatto [S.America]
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MEDICAL ADVISORY COUNCIL
Chair
Mahesh Shetty MD;FRCR;FACR;FAIUM
Clinical Professor of Radiology
Baylor College of Medicine
Members
Dr. Steve Sener
Former President
American Cancer Society
R. Sankaranarayanan
Chief of Cancer Screening Group
International Agency for Research on Cancer,
WHO
Lyon, France
Saraswati Sukumar MD
Barbara B.Rubenstein Professor of Oncology
Johns Hopkins University School of Medicine
Britt-Marie Ljung, MD
Professor of Clinical Pathology,
Director of Cytopathology
UCSF, California
Dr Usha Menon MD; FRCOG
Professor and Director
Gynecological Cancer Research Center
UCL Elizabeth Garrett Institute of Women's Health
University College London
Dr Edmundo Mauad
Director
Barretos Cancer Hospital,
Sao Paulo, Brazil
Peter Dempsey MD; FACR
Professor of Radiology
MD Anderson Cancer Center
Terri Pustilnik MD
Gynecology Oncology of Houston
Dr Diljeet K. Singh, MD, DrPH
Co Chair of MAC
Dr Wei Yang, M.B.B.S., F.R.C.R.
Professor
Deputy Chairman,
Department of Diagnostic Radiology
The University of Texas, M.D. Anderson Cancer Center
Co-Chair and Director of Clinical Research
Dr Neerja Bhatla MD, FICOG
A/Professor, Dept of Ob-Gyn, All India Institute of Medical Sciences, New Delhi, India,
Vice President, AOGIN,
Inaugural President, AOGIN-India,
Organising Chairperson, AOGIN 2010
Dr Jill Donnelly
Consultant Breast Surgeon
Herford Hospital, UK
Dr Martin M. Matzuk M.D., Ph.D.
Stuart A. Wallace Chair
Professor of Pathology and Immunology
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PUBLIC AWARENESS COUNCIL
Mrs. Susan Rafte
Chair of the PAC
Mrs. Sathya Saran
Co-chair,
Editor DNA,
Former Editor, Femina,
Mumbai, India
Ms. Lucy Noland
Co-chair,
News Anchor,
KNBC,
Los Angeles
Sharda Cherwoo
Partner
Ernst & Young
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Sara Sukumar
Professor of Oncology and Pathology |
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Contact Information
Room 410, Cancer Research Building
410-614-2479
410-614-4073 (Fax)
saras@jhmi.edu
Research Interests
Molecular Genetics of Breast Cancer
The goal of the laboratory is to identify gene alterations, to study the consequences of these changes to the cellular machinery, and to translate this knowledge to early detection and novel therapies for breast cancer. We have identified a large number of candidate oncogenes and tumor suppressor genes by SAGE and microarray analysis. Among these, we are currently analyzing tight junction proteins, Claudin-3, -4 and 7 and the homeotic genes, HOXA5 and HOXB7. HOXA5 is a potent transcriptional regulator of the progesterone receptor and the p53 gene, and its expression is lost in breast cancer cells. Few HOXA5 minus mice survive; the females have defects in lactation. HOXB7, on the other hand, is over expressed in breast cancer, and induces production of growth factors in cancer cells.
Future directions:
Study of mammary development and breast tumorigenesis in conditional knockout mice for HOXA5, and in transgenic mice overexpressing HOXB7.
Role of Claudin-7 in metastasis using imaging techniques, mammary development in transgenic mice and proteomic analysis of genes induced by Claudin-7 overexpression.
Selected Publications
Chen H, Chung S and Sukumar S. Hoxa5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. Molecular Cellular Biology, 24: 924-935, 2004.
Mehrotra J, Ganpat MM, Kanaan Y, Fackler MJ, McVeigh M,
Lahti- Domenici J, Polyak, K, Argani P, Naab, T, Garrett E, Parmigiani G, Broome C and Sukumar S. ER/PR-negative breast cancers of young African American women have a higher frequency of methylation of multiple genes than those of Caucasian women. Clin Cancer Res. 10:2052-2057, 2004.
Zhu T, and Sukumar S. Coupling the transcriptional regulatory action of brn-3b to the cell cycle clock. Cancer Biol and Therapy, 3: 324-325, 2004.
Kominsky SL, Vali M, Korz M, Gabig TG, Garrett E, Argani P, and Sukumar S. Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins Claudin 3 and 4. Amer J Pathol, 164:1627-1633, 2004.
Mehrotra J, Vali M, McVeigh M, Kominsky SL, Fackler MJ,
Lahti- Domenici J, Polyak K, Sacchi N, Argani P, and Sukumar S. Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. Clin Cancer Res. 10: 3104- 3109, 2004.
Fackler MJ, McVeigh M, Mehrotra J, Blum MA, Lange J, Lapides A, Garrett E, Argani P, and Sukumar S. Quantitative multiplex methylation specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res. 64:4442-4452, 2004.
Parker BS, Argani P, Cook BP, Han L, Chatrand SD, Zhang M, Saha S, Bardelli A, Yiang Y, St. Martin TB, Nacht M, Teicher B, Klinger KW, Sukumar S, and Madden S. Alterations in vascular gene expression in invasive breast carcinoma. Cancer Res.64: 7857-7866 2004.
Fackler, MJ, McVeigh M, Evron E, Garrett E, Mehrotra J, Polyak, Sukumar S, Argani P. DNA methylation of RASSF1A, HIN-1,
RAR- beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int. Journal of Cancer 107, 970-975, 2003.
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